Vitabiotics

ULTRA VITAMIN D

ULTRA VITAMIN D contains vitamin D3 in the form of cholecalciferol, which contributes to normal calcium absorption and maintains bone and tooth health.
Vitamin D has several key functions:
- helps absorb calcium from food ref 1
- has a nonsignificant regulatory effect on parathyroid hormone level ref 2, thereby lowers the bone mass reduction ref 3
- provides adequate bone regeneration and mineralization ref 4
- has a direct stimulating effect on muscle tissue ref 5 and thus reduces the risk of falls
- support for normal functioning of the immune system ref 6


ADEQUATE INTAKE OF VITAMIN D IS A PREREQUISITE FOR EFFECTIVE OSTEOPOROSIS THERAPY ref 7
VITAMIN D SUPPLEMENTATION SHOULD BE USED BEFORE BISPHOSPHONATE OSTEOPOROSIS THERAPY ref 8
References:
1. Heaney RP et al Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr 2003 Apr; 22(2): 142-6.
2. Steingrimsdottir L et al. Relationship between serum parathyroid hormone levels, vitamin D suffciency and calcium intake. JAMA. 2005 Nov 9; 294 (18): 2336-42.
3. Dowson-Highes B et al. E_ect of calcium and vitamin D supplementation on bone density in men and woman 65 years of age and older. N Engl J Med. 1997 Sep 4; 337(10): 670-6.
4. Priemel Metal. Bonmineralization defects and vitamin D deffciency: histomorphometricanalysisofiliaccrestbonebiopsyandcirculating25-hydroxyvitaminDin675patients. JBoneMinerRes2011Feb;25
(2):305-12.
5. Ceglia L et al. Multi-step immunofuoroscent analysis of vitamin d receptor loci and myosin heavy chain isoforms in human skeletal muscle. J Mol Histol. 2010 Apr; 41 (2-3); 137-42.
6. Bischofl-Ferrari et al. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomized controlled trials. BMJ. 2009; 339:b3692.
7. Diez-Perez A, et al. (2012) Risk factors for prediction of inadequate response to antiresorptives. J Bone Miner Res 27:817–824.
8. Rizzoli R, et al. (2013) Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects
of Osteoporosis and Osteoarthritis (ESCEO). Curr Med Res Opin 29:305–313.

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