Serapeptase is an enzyme created as a product of Serratia bacteria 1 and belongs to a broad group of proteolytic enzymes. It effects almost all organ systems in which exists pathological processes and are followed by inflammation, swelling, pain, pus, mucus or hematoma 2.
The effects of serapeptase:
This effect of serapeptase is realized due to its affinity for bradykinin breakdown.
Bradykinin is a chemical mediator of protein structure, present in zones where it exists inflammation - dilates blood vessels, and irritates pain-transmitting nerve receptors3.
Serapeptase reduces swelling by breaking down excess protein and accelerating lymph drainage.
The breakdown of bradykinin reduces the stimulation of pain receptors and analgesic effect is achieved. In addition, it indirectly reduces pain by doing so decreases swelling that mechanically activates nearby nerve receptors4.
Serapeptase reduces the number of cells that accumulate in the mucus, and decomposes it proteins 1.
FlamIN and FlamIN FORTE is advised:
* to reduce SWELLING:
- after surgical interventions, especially maxillofacial and other surgical interventions in the oral cavity (there is evidence for the synergistic effect of serapeptase with antibiotics in various tool-borne infections) 5
-Compression syndromes (Sy carpal tunnel) and some occlusive conditions 6
* for INJURIES:
-Flexes, dislocations, fractures, sports injuries, etc.
-Additionally, it may also be useful in rheumatoid arthritis and osteoarthritis, in addition to regular therapy
-to facilitate the expulsion of thick, viscous SECRETION, especially from the upper and lower respiratory tract (acute and chronic sinusitis, rhinopharyngitis, etc.)
-Fibromatous changes and cysts, so it can be useful for fibrocystic breasts and other cystic structures on urogenital organs
1 Nakahama K, Yoshimura K, Marumoto R, Kikuchi M. Cloning and sequencing of Serratia protease gene. Nucl Acids Res 1986;14:5843e55.
2 Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, et al. Evaluation of Serratia-peptidase in acute or chronic infl ammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379e88
3 Koyama A, Mori J, Tokuda H, Waku M, Anno H, Katayama T, Murakami K, Komatsu H, Hirata M, Arai T, et al. Augmentation by serrapeptase of tissue permeation by cefotiam. Jpn J Antibiot.1986 Mar;39(3):761-71.
4 Richa Garg, Shafi qa Aslam, Anil Garg & Rani Walia. A Prospective Comparative Study of serratiopeptidase and aceclofenac in Upper and Lower LimbSoft Tissue Trauma Cases International Journal of Pharmacology and Pharmaceutical Technology (IJPPT), ISSN: 2277 – 3436, Volume-1, Issue- 2, 201
5 Sannino G, Gigola P, Puttini M, Pera F, Passariello C. Combination therapy including serratiopeptidase improves outcomes of mechanical-antibiotic treatment of periimplantitis. Int J Immunopathol Pharmacol. 2013 Jul-Sep;26(3):825-31. ili ova Al-Khateeb TH, Nusair Y. Eff ect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars. Int J Oral Maxillofac Surg. 2008 Mar;37(3):264-8. doi: 10.1016/j.ijom.2007.11.011. Epub 2008 Feb 12.
6 Panagariya A, Sharma AK. A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome. J Assoc Physicians India. 1999 Dec;47(12):1170-2.